Toward the total synthesis of luminamicin; An anaerobic antibiotic: Construction of highly functionalized cis-decalin containing a bridged ether moiety

Hiroyasu Ando, Aoi Kimishima, Motoyoshi Ohara, Tomoyasu Hirose, Takanori Matsumaru, Hirokazu Takada, Keisuke Morodome, Takehiro Miyamoto, Akihiro Sugawara, Satoshi Mura, Toshiaki Sunazuka

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Synthesis of a cis-decalin moiety, containing an oxa-bridged cis-decalin ring system (11-oxatricyclo(5.3.1. 1,7 0 3,8)undecane), as a key intermediate of the total synthesis of luminamicin (1) was accomplished. One of the essential steps in our synthetic route is construction of a cis-decaline framework using a one-pot Michael addition-aldol reaction. Additionally, the bridged ether moiety was obtained by an intramolecular 1,6-oxa-Michael reaction of a conjugated aldehyde.

本文言語English
ページ(範囲)268-272
ページ数5
ジャーナルJournal of Antibiotics
71
2
DOI
出版ステータスPublished - 2018 2 1
外部発表はい

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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