TY - JOUR
T1 - Tranilast inhibits the effects of platelet-derived growth factor on cell priliferation and induction of nitric oxide
AU - Hishikawa, Keiichi
AU - Nakaki, Toshio
AU - Hirahashi, Junichi
AU - Marumo, Takeshi
AU - Saruta, Takao
PY - 1995/11/30
Y1 - 1995/11/30
N2 - The effects of tranilast on DNA synthesis and cell proliferation in cultured rat mesangial cells, treated with platelet-derived growth factor (PDGF), were investigated. Tranilast significantly inhibited PDGF-stimulated DNA synthesis and cell proliferation in a dose-dependent manner. In the absence of PDGF, it also enhanced cytokine-induced nitric oxide (NO) production. PDGF significantly inhibited cytokine-induced NO production, but tranilast completely abolished this inhibitory effect of PDGF. These results show that tranilast inhibits PDGF-induced proliferation of mesangial cells under both normal and inflammatory conditions.
AB - The effects of tranilast on DNA synthesis and cell proliferation in cultured rat mesangial cells, treated with platelet-derived growth factor (PDGF), were investigated. Tranilast significantly inhibited PDGF-stimulated DNA synthesis and cell proliferation in a dose-dependent manner. In the absence of PDGF, it also enhanced cytokine-induced nitric oxide (NO) production. PDGF significantly inhibited cytokine-induced NO production, but tranilast completely abolished this inhibitory effect of PDGF. These results show that tranilast inhibits PDGF-induced proliferation of mesangial cells under both normal and inflammatory conditions.
KW - Mesangial cell
KW - Nitric oxide (NO)
KW - PDGF (platelet-derived growth factor)
KW - Tranilast
UR - http://www.scopus.com/inward/record.url?scp=0028881094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028881094&partnerID=8YFLogxK
U2 - 10.1016/0922-4106(95)90087-X
DO - 10.1016/0922-4106(95)90087-X
M3 - Article
C2 - 8719431
AN - SCOPUS:0028881094
SN - 0922-4106
VL - 291
SP - 435
EP - 438
JO - European Journal of Pharmacology - Molecular Pharmacology Section
JF - European Journal of Pharmacology - Molecular Pharmacology Section
IS - 3
ER -