Transcription Factors and Epigenetic Modulation: Its Therapeutic Implication in Chronic Kidney Disease

研究成果: Review article査読

6 被引用数 (Scopus)

抄録

Recently emerging evidence has shown that epigenetic mechanisms are involved in initiation and progression of various diseases, including kidney diseases. In the present article, we review the current data regarding the role of epigenetic modulation in chronic kidney disease (CKD) and kidney fibrosis, including DNA methylation and histone modification. Especially we focused on the role of transcription factors in epigenetic modulation and the possibility of therapeutic target of CKD. We have recently reported that transcription factor Kruppel-like factor 4 (also known as gut-enriched Kruppel-like factor) is expressed in kidney podocytes (visceral epithelial cells) and modulates podocyte phenotype by gene-selective epigenetic control. Targeting transcription factors for epigenetic modification may be a good candidate for remission and regression of CKD. It is necessary for the therapy of CKD with an epigenetic-based approach to investigate organ-, tissue-, or gene-specific treatment methods for reduction of side effects.

本文言語English
ページ(範囲)193-196
ページ数4
ジャーナルArchivum Immunologiae et Therapiae Experimentalis
63
3
DOI
出版ステータスPublished - 2015 6月 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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