Transcriptome Analysis of Adrenocortical Cells in Health and Disease

研究成果: Chapter

2 被引用数 (Scopus)

抄録

The transcriptome is the complete set of transcripts in a specific type of cell or tissue. Generally, the goal of transcriptome analysis is to identify genes differentially expressed among different conditions, leading to a new understanding of the genes or pathways associated with the conditions. Transcriptome analysis requires an appropriate statistical method with a multiple comparison test to interpret global changes in the expression of thousands of genes. This chapter reviews and describes recent progress in transcriptome analysis of adrenocortical cells. Strategies for determining transcriptomes and data mining to interpret analysis are discussed. Representative studies are introduced, including a mouse model for human lipoid adrenal hyperplasia that proposes, as a new pathophysiological hallmark, a reciprocal interaction between adrenocortical cells and infiltrated macrophages. Analysis of global transcript profiling will be an essential tool for future research on the nature of adrenocortical cells.

本文言語English
ホスト出版物のタイトルCellular Endocrinology in Health and Disease
出版社Elsevier Inc.
ページ169-192
ページ数24
ISBN(印刷版)9780124081345
DOI
出版ステータスPublished - 2014 5

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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