Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells

Takashi Yamaoka, Takefumi Matsui, Takashi Yamaguchi, Maki Moritani, Mitsuo Itakura, Kenji Yoshino, Makiko Yano, Taketo Yamada, Jun ichi Hata, Sumihare Noji

研究成果: Article査読

20 被引用数 (Scopus)

抄録

FGF signaling is essential for normal development of pancreatic islets. To examine the effects of overexpressed FGF8 and FGF10 on pancreatic development, we generated FGF8- and FGF10-transgenic mice (Tg mice) under the control of the glucagon promoter. In FGF8-Tg mice, hepatocyte-like cells were observed in the periphery of pancreatic islets, but areas of α and β cells did not decrease, whereas in FGF10-Tg mice, pancreatic ductal and acinar cells were found in islets, concomitantly with disturbed β-cell differentiation. These results suggest that FGF8 and FGF10 play important roles in development of hepatocytes and exocrine cells, respectively, and explain the absence of FGF8 expression in normal islets and pancreatic hypoplasia in FGF10-deficient mice.

本文言語English
ページ(範囲)138-143
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
292
1
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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