Translocation (8; 22) (q24; q11) and Epstein-Barr viral genome in a case of Burkitt's type of acute lymphoblastic leukemia (L3)

T. Watanabe, S. Okamoto, H. Nakamura, N. Sadamori, K. Kinoshita, M. Ichimaru

研究成果: Article査読

抄録

A case of Burkitt's type of acute lymphoblastic leukemia (FAB L3) in an 80-year-old male patient is reported. At the time of diagnosis, 74% of the bone marrow cells were lymphoblastoid cells, which were large and homogeneous in size, and whose cytoplasm was abundant and intensely basophilic containing many vacuoles. Lambda-light chains were detected as surface immunoglobulin (Ig), but not heavy chains or kappa-light chains. Epstein-Barr (EB) viral genome was detected in the cultured bone marrow cells by spot hybridization method. Chromosomal banding studies of bone marrow cells revealed t(8; 22) (q24; q11) in all the 18 metaphases examined. This translocation brings the Ig lambda-light chain gene on chromosome 22q11 to chromosome 8q24 where the c-myc proto-oncogene is localized, which is thought to be closely associated with the leukemogenesis of this disorder, whereas EB viral genome is observed in African Burkitt's lymphoma. To our best knowledge, however, there have been no reported Japanese patients with L3 ALL in whom t(8; 22) or EB viral genome was observed.

本文言語English
ページ(範囲)211-215
ページ数5
ジャーナル[Rinsho ketsueki] The Japanese journal of clinical hematology
30
2
出版ステータスPublished - 1989 2月
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

フィンガープリント

「Translocation (8; 22) (q24; q11) and Epstein-Barr viral genome in a case of Burkitt's type of acute lymphoblastic leukemia (L3)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル