Transplantation of neural stem cells into the spinal cord after injury

Hideyuki Okano, Yuto Ogawa, Masaya Nakamura, Shinjiro Kaneko, Akio Iwanami, Yoshiaki Toyama

研究成果: Article査読

84 被引用数 (Scopus)


Thanks to advances in the stem cell biology of the central nervous system (CNS), the previously inconceivable regeneration of the damaged CNS is approaching reality. The availability of signals to induce the appropriate differentiation of the transplanted and/or endogenous neural stem cells (NSCs) as well as the timing of the transplantation are important for successful functional recovery of the damaged CNS. Because the immediately post-traumatic microenvironment of the spinal cord is in an acute inflammatory stage, it is not favorable for the survival and differentiation of NSC transplants. On the other hand, in the chronic stage after injury, glial scars form in the injured site that inhibit the regeneration of neuronal axons. Thus, we believe that the optimal timing of transplantation is 1-2 weeks after injury.

ジャーナルSeminars in Cell and Developmental Biology
出版ステータスPublished - 2003 6月

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学


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