Treatment of persistent corneal epithelial defect by autologous serum application

Kazuo Tsubota, Eiki Goto, Shigeto Shimmura, Jun Shimazaki

研究成果: Article

264 引用 (Scopus)

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Objective: To evaluate the efficacy of autologous serum application for the treatment of persistent epithelial defect. Design: Prospective, clinical, noncomparative case series. Participants: A total of 16 eyes were studied. Intervention: Autologous serum was prepared from the patients and diluted to 20% by saline. The patients were instructed to use the autologous serum six to ten times a day. The concentration of vitamin A, epidermal growth factor (EGF), and transforming growth factor-β (TGF-β) was measured at 1 week and 1 month stored in the refrigerator and 1 month and 3 months in the freezer. Main Outcome Measures: Time to closure of epithelial defect. Results: Vitamin A, EGF, and TGF-β were stable during the 1 month in the refrigerator and 3 months in the freezer. Among 16 persistent epithelial defects, 7 (43.8%) healed within 2 weeks, 3 (18.8%) healed within 1 month, and the remaining 6 (37.5%) did not respond within 1 month. No apparent side effect of autologous serum application was observed. Conclusions: Autologous serum application healed 43.8% of persistent defect within 2 weeks and 62.5% within 1 month.

元の言語English
ページ(範囲)1984-1989
ページ数6
ジャーナルOphthalmology
106
発行部数10
出版物ステータスPublished - 1999 10 1

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Serum
Transforming Growth Factors
Vitamin A
Epidermal Growth Factor
Therapeutics
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

これを引用

Treatment of persistent corneal epithelial defect by autologous serum application. / Tsubota, Kazuo; Goto, Eiki; Shimmura, Shigeto; Shimazaki, Jun.

:: Ophthalmology, 巻 106, 番号 10, 01.10.1999, p. 1984-1989.

研究成果: Article

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title = "Treatment of persistent corneal epithelial defect by autologous serum application",
abstract = "Objective: To evaluate the efficacy of autologous serum application for the treatment of persistent epithelial defect. Design: Prospective, clinical, noncomparative case series. Participants: A total of 16 eyes were studied. Intervention: Autologous serum was prepared from the patients and diluted to 20{\%} by saline. The patients were instructed to use the autologous serum six to ten times a day. The concentration of vitamin A, epidermal growth factor (EGF), and transforming growth factor-β (TGF-β) was measured at 1 week and 1 month stored in the refrigerator and 1 month and 3 months in the freezer. Main Outcome Measures: Time to closure of epithelial defect. Results: Vitamin A, EGF, and TGF-β were stable during the 1 month in the refrigerator and 3 months in the freezer. Among 16 persistent epithelial defects, 7 (43.8{\%}) healed within 2 weeks, 3 (18.8{\%}) healed within 1 month, and the remaining 6 (37.5{\%}) did not respond within 1 month. No apparent side effect of autologous serum application was observed. Conclusions: Autologous serum application healed 43.8{\%} of persistent defect within 2 weeks and 62.5{\%} within 1 month.",
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N2 - Objective: To evaluate the efficacy of autologous serum application for the treatment of persistent epithelial defect. Design: Prospective, clinical, noncomparative case series. Participants: A total of 16 eyes were studied. Intervention: Autologous serum was prepared from the patients and diluted to 20% by saline. The patients were instructed to use the autologous serum six to ten times a day. The concentration of vitamin A, epidermal growth factor (EGF), and transforming growth factor-β (TGF-β) was measured at 1 week and 1 month stored in the refrigerator and 1 month and 3 months in the freezer. Main Outcome Measures: Time to closure of epithelial defect. Results: Vitamin A, EGF, and TGF-β were stable during the 1 month in the refrigerator and 3 months in the freezer. Among 16 persistent epithelial defects, 7 (43.8%) healed within 2 weeks, 3 (18.8%) healed within 1 month, and the remaining 6 (37.5%) did not respond within 1 month. No apparent side effect of autologous serum application was observed. Conclusions: Autologous serum application healed 43.8% of persistent defect within 2 weeks and 62.5% within 1 month.

AB - Objective: To evaluate the efficacy of autologous serum application for the treatment of persistent epithelial defect. Design: Prospective, clinical, noncomparative case series. Participants: A total of 16 eyes were studied. Intervention: Autologous serum was prepared from the patients and diluted to 20% by saline. The patients were instructed to use the autologous serum six to ten times a day. The concentration of vitamin A, epidermal growth factor (EGF), and transforming growth factor-β (TGF-β) was measured at 1 week and 1 month stored in the refrigerator and 1 month and 3 months in the freezer. Main Outcome Measures: Time to closure of epithelial defect. Results: Vitamin A, EGF, and TGF-β were stable during the 1 month in the refrigerator and 3 months in the freezer. Among 16 persistent epithelial defects, 7 (43.8%) healed within 2 weeks, 3 (18.8%) healed within 1 month, and the remaining 6 (37.5%) did not respond within 1 month. No apparent side effect of autologous serum application was observed. Conclusions: Autologous serum application healed 43.8% of persistent defect within 2 weeks and 62.5% within 1 month.

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