Treatment of secondary infection, especially septicemia in hematological patients with KW-1070

Nine hematological patients as acute leukemia, aplastic anemia and multiple myeloma were treated with KW-1070, a new aminoglycoside, or in combination with other antibiotics. Maximum blood concentration measured by radioimmunoassay was about 14 µg/ml when 200 mg of KW-1070 was given by one-hour drip intravenous infusion as well as by intramuscular injection. Out of 9 cases consisted of 4 cases with septicemia, 4 possible septicemia and 1 urinary tract infection, 4 cases were cured by treatment with KW-1070. Septicemin caused by Klebsiella pneumoniae in a case with acute leukemia was cured by treatment with KW-1070 and cephalothin, as Klebsiella isolated from the patient was sensitive to KW-1070 while not gentamicin or dibekacin. In none of 9 cases, any side effect snch as hearing disturbance or impaired renal function was observed.