Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: multi-center open trial.

Osamu Kanauchi, Keiichi Mitsuyama, Terasu Homma, Kazuya Takahama, Yoshihide Fujiyama, Akira Andoh, Yoshio Araki, Toshihiro Suga, Toshifumi Hibi, Makoto Naganuma, Hitoshi Asakura, Hiroshi Nakano, Takashi Shimoyama, Nobuyuki Hida, Ken Haruma, Hideki Koga, Michio Sata, Nobuo Tomiyasu, Atsushi Toyonaga, Masanobu FukudaAtsushi Kojima, Tadao Bamba

研究成果: Article査読

97 被引用数 (Scopus)

抄録

Germinated barley foodstuff (GBF), which mainly consists of dietary fiber and glutamine-rich protein, is a prebiotic for ulcerative colitis (UC). In our previous study, we carried out a clinical trial of GBF with mildly to moderately active UC patients and showed that GBF treatment was able to attenuate the symptoms of UC in a relatively short-term. The aim of this study was to investigate the efficacy of long-term administration of GBF in the treatment of UC in a multi-center open trial. Twenty-one patients with mildly to moderately active UC received 20-30 g of GBF for 24 weeks in an open-label protocol while baseline treatments (5-amino-salicyrate compounds and/or steroids) were continued. The response to the GBF treatment was evaluated using a clinical scoring and after 24 weeks of observation, the GBF group showed a significant decrease in clinical activity index (especially, the degree of visible blood in stools and the presence of nocturnal diarrhea) compared with the control group (p<0.05). No side effects related to GBF were observed. In conclusion, GBF can reduce the clinical activity of UC over long-term as well as short-term administration. Nutraceutical GBF therapy may have a place in long-term management of UC, but controlled studies are needed to demonstrate its efficacy in the treatment of this disorder.

本文言語English
ページ(範囲)701-704
ページ数4
ジャーナルInternational journal of molecular medicine
12
5
DOI
出版ステータスPublished - 2003 11
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

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