Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury

Toshiki Okubo, Narihito Nagoshi, Jun Kohyama, Osahiko Tsuji, Munehisa Shinozaki, Shinsuke Shibata, Yoshitaka Kase, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano

研究成果: Article

9 引用 (Scopus)

抄録

In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.

元の言語English
ページ(範囲)1416-1432
ページ数17
ジャーナルStem Cell Reports
11
発行部数6
DOI
出版物ステータスPublished - 2018 12 11

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Induced Pluripotent Stem Cells
Amyloid Precursor Protein Secretases
Transplants
Spinal Cord Injuries
Synapses
Transplantation
Recovery
Fibers

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

これを引用

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AU - Okubo, Toshiki

AU - Nagoshi, Narihito

AU - Kohyama, Jun

AU - Tsuji, Osahiko

AU - Shinozaki, Munehisa

AU - Shibata, Shinsuke

AU - Kase, Yoshitaka

AU - Matsumoto, Morio

AU - Nakamura, Masaya

AU - Okano, Hideyuki

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KW - Notch signaling

KW - p38 MAPK

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