Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury

Toshiki Okubo, Narihito Nagoshi, Jun Kohyama, Osahiko Tsuji, Munehisa Shinozaki, Shinsuke Shibata, Yoshitaka Kase, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano

研究成果: Article査読

17 被引用数 (Scopus)

抄録

In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.

本文言語English
ページ(範囲)1416-1432
ページ数17
ジャーナルStem cell reports
11
6
DOI
出版ステータスPublished - 2018 12 11

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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