Trends in hepatocyte growth factor, insulin-like growth factor 1, thyroid-stimulating hormone, and leptin expression levels in uveal melanoma patient serum and tumor tissues: Correlation to disease progression

Junna Oba, Bita Esmaeli, Julie A. Ellerhorst, Genevieve R. Lyons, Denái R. Milton, Wei Lien Wang, Mariana P. Macedo, Alexander J. Lazar, Elizabeth A. Grimm, Chandrani Chattopadhyay

研究成果: Article査読

4 被引用数 (Scopus)

抄録

This exploratory study was carried out to determine the expression levels of hepatocyte growth factor (HGF), insulin-like growth factor 1, thyroid-stimulating hormone (TSH), and leptin in serum and tumor samples from patients with uveal melanoma and to investigate the potential association of these expression levels with disease progression and patient survival. Seventeen patients, including nine nonmetastatic and eight metastatic, were included in the study. Eighteen healthy individuals served as controls. The levels of these four proteins in serum and tissue samples were determined by enzyme-linked immunosorbent assays and immunohistochemical staining, respectively. Associations between protein levels and survival, disease progression, and other clinicopathological factors were analyzed statistically. Serum levels of HGF were significantly higher and TSH levels were lower in uveal melanoma patients than in healthy individuals, but the level of neither protein differed significantly between metastatic and nonmetastatic groups. Of the four proteins tested, only serum TSH was significantly associated with patient survival. No correlation was observed between the tissue and serum levels of each protein. The levels of HGF in serum may be markers of uveal melanoma development. The prognostic and predictive values of these potential markers need to be determined in a larger cohort.

本文言語English
ページ(範囲)126-133
ページ数8
ジャーナルMelanoma Research
27
2
DOI
出版ステータスPublished - 2017
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 皮膚病学
  • 癌研究

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