Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. Structure elucidation

Yushi Futamura, Etsu Tashiro, Naoka Hironiwa, Jun Kohno, Maki Nishio, Kazutoshi Shindo, Masaya Imoto

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.

本文言語English
ページ(範囲)582-585
ページ数4
ジャーナルJournal of Antibiotics
60
9
DOI
出版ステータスPublished - 2007 9

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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