Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation

Michiko N. Fukuda, Takaaki Sato, Jun Nakayama, George Klier, Mikio Mikami, Daisuke Aoki, Shiro Nozawa

研究成果: Article査読

166 被引用数 (Scopus)

抄録

Two human epithelial cell lines, trophoblastic teratocarcinoma HT-H and endometrial adenocarcinoma SNG-M cells, adhere to each other at their respective apical cell surfaces in a divalent cation-independent manner. Two novel molecules responsible for the adhesion between these two cell types were identified by expression cDNA cloning. One, named trophinin, is an intrinsic membrane protein and mediates homophilic serf-binding. Another, named tastin, is a cytoplasmic protein and is necessary for trophinin to function as a cell adhesion molecule. Trophinin and tastin appear to be associated with the cytoskeleton in HT-H and SNG-M cells. These molecules are normally not expressed in various types of human cells in tissues, with the exception of macrophages. Strong expression of these molecules was detected in the trophectoderm surface of monkey blastocyst. These molecules are also expressed in human endometrial surface epithelium on day 16/17 at the early secretory phase of human endometrium, the time consistent with that expected for the 'implantation window.'

本文言語English
ページ(範囲)1199-1210
ページ数12
ジャーナルGenes and Development
9
10
DOI
出版ステータスPublished - 1995 5月 15

ASJC Scopus subject areas

  • 遺伝学
  • 発生生物学

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