Trypanocidal constituents from Michelia alba

Mohd Razip Asaruddin, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki, Fumiyuki Kiuchi

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The AcOEt extract of the bark of M. alba D.C. (Magnoliaceae) exhibited killing activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded eight trypanocidal constituents; caryophyllene oxide (1), costunolide (2), dihydrocostunolide (3), parthenolide (4), dihydroparthenolide (5), 11, 13-dehydrolanuginolide (6) santamarine (7) and a new monoterpene (8). The structure of monoterpene 8 was determined to be dehydrolinalool oxide on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 61 μM, 7 μM, 27 μM, 0.04 μM, 0.78 μM, 0.16 μM, 25 μM, and 5 μM, respectively.

本文言語English
ページ(範囲)61-63
ページ数3
ジャーナルNatural Medicines
57
2
出版ステータスPublished - 2003 4月 1
外部発表はい

ASJC Scopus subject areas

  • 分子医療

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