Trypanocidal constituents of Dracocephalum komarovi

Nahoko Uchiyama, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Trypanocidal constituents of Dracocephalum komarovi were investigated. Under guidance of the in vitro trypanocidal activity against epimastigotes of Trypanosoma cruzi, the causative agent of Chagas' disease, two new diterpenes, dracocequinones A (1) and B (2), and two known triterpene acids, ursonic acid and ursolic acid, were isolated as trypanocidal constituents, in addition to previously reported diterpenes, cyclocoulterone (4), komaroviquinone (5), dracocephalone A (6) and komarovispirone (7). Furthermore a new diterpene, komarovinone A (3), was isolated, together with four known terpenes. Among these compounds, komaroviquinone (5) showed the most potent activity with minimum lethal concentration of 0.4 μM. Structure elucidation of the new diterpenes 1-3 was described.

本文言語English
ページ(範囲)4355-4359
ページ数5
ジャーナルTetrahedron
62
18
DOI
出版ステータスPublished - 2006 5月 1
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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