Trypanocidal Flavonoids from Sophora flavescens

Kenji Matsuo, Michiho Ito, Gisho Honda, Tran Kim Qui, Fumiyuki Kiuchi

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-) -kurarinone (2), kushenol L (3), 2′-methoxykurarinone, (5), 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM (1), 14 μM (2), 7.1 μM (3), 7.2 μM (4), 6.9 μM (5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).

本文言語English
ページ(範囲)253-255
ページ数3
ジャーナルNatural Medicines
57
6
出版ステータスPublished - 2003 12月 1
外部発表はい

ASJC Scopus subject areas

  • 分子医療

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