Trypanocidal terpenoids from Laurus nobilis L.

Nahoko Uchiyama, Keiji Matsunaga, Fumiyuki Kiuchi, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki

研究成果: Article査読

39 被引用数 (Scopus)

抄録

Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.

本文言語English
ページ(範囲)1514-1516
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
50
11
DOI
出版ステータスPublished - 2002 11
外部発表はい

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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