Tube-Shaped In-Vitro Intestinal Gut Model with 3D Isotropic Medium Supply for Bacterial Symbiosis

Mitsuki Kawahara, Shun Itai, Hiroaki Onoe

研究成果: Conference contribution

抄録

This paper describes a tube-shaped in vitro intestinal gut model achieving both isotropic medium supply and stable co-culture with bacteria. Our tube-shaped device consists of a collagen/Matrigel tube as a scaffold for intestinal cells and glass/silicone tubes at both ends for perfusion. We confirmed intestinal cells (Caco-2) can be maintained in the luminal part with nutrient-free buffer flow mimicking bacterial suspensions and demonstrated the co-culture of Escherichia-coli (E. coli) in the Caco-2 cultured tube-shaped device. We believe this device provides ple but stable co-culture model with intestinal cells and bacteria and contributes to medical field research relating intestinal bacteria.

本文言語English
ホスト出版物のタイトル35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
出版社IEEE Computer Society
ページ321-324
ページ数4
ISBN(電子版)9781665409117
DOI
出版ステータスPublished - 2022
イベント35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 - Tokyo, Japan
継続期間: 2022 1月 92022 1月 13

出版物シリーズ

名前IEEE Symposium on Mass Storage Systems and Technologies
2022-January
ISSN(印刷版)2160-1968

Conference

Conference35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
国/地域Japan
CityTokyo
Period22/1/922/1/13

ASJC Scopus subject areas

  • ハードウェアとアーキテクチャ
  • 電子工学および電気工学

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