Tublogenesis of endothelial cells in core-shell hydrogel microfibers

Hiroaki Onoe, Shoji Takeuchi

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

This paper describes tube formation of endothelial cells in collagen/alginate core-shell hydrogel microfiber. We found that encapsulated MS1 (mouse pancreatic endothelial cell line) and HUVEC (human umbilical vein endothelial cell) spontaneously create tube-like monolayer cell structures along the axial direction of the fiber at meter-length scale. Because the produced endothelial tubes are free-standing and handleable in a culture medium with the support of the alginate shell, our endothelial cell fibers would be a fundamental tissue unit for constructing three-dimensional (3D) macroscopic tissues with vascular network and for analyzing cellular behaviors (ex. vasculogenesis or angiogenesis) under intercellular/chemical/mechanical/fluidic interactions.

本文言語English
ホスト出版物のタイトルProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
出版社Chemical and Biological Microsystems Society
ページ1069-1071
ページ数3
ISBN(印刷版)9780979806452
出版ステータスPublished - 2012 1月 1
外部発表はい
イベント16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
継続期間: 2012 10月 282012 11月 1

出版物シリーズ

名前Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
国/地域Japan
CityOkinawa
Period12/10/2812/11/1

ASJC Scopus subject areas

  • 化学工学(その他)
  • バイオエンジニアリング

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