Tumor immunity against adult T-cell leukemia

Mari Kannagi, Nanae Harashima, Kiyoshi Kurihara, Takashi Ohashi, Atae Utsunomiya, Ryuji Tanosaki, Masato Masuda, Masao Tomonaga, Jun Okamura

研究成果: Review article査読

32 被引用数 (Scopus)

抄録

Human T-cell leukemia virus type-I (HTLV-I) causes adult T-cell leukemia (ATL) in a small population of infected individuals after a long incubation period. Although the process of clonal evolution of ATL cells may involve multiple steps, ATL cells from half of the ATL cases still retain the ability to express HTLV-I Tax, a key molecule of HTLV-I leukemogenesis. A recent finding of reactivation of Tax-specific cytotoxic T lymphocytes (CTL) in ATL patients after hematopoietic stem cell transplantation suggests the presence of Tax expression in vivo and potential contribution of the CTL to antitumor immunity. This is consistent with the results of a series of animal experiments indicating that Tax-specific CTL limit the growth of HTLV-I-infected cells in vivo, although the animal model mimics only an early phase of HTLV-I infection and leukemogenesis. Establishment of an insufficient HTLV-I-specific T-cell response and an increased viral load in orally HTLV-I-infected rats suggests that host HTLV-I-specific T-cell response at a primary HTLV-I infection can be a critical determinant of persistent HTLV-I levels thereafter. These findings indicate that Tax-targeted vaccines may be effective for prophylaxis of ATL in a high-risk group, and also for therapy of ATL in at least half the cases.

本文言語English
ページ(範囲)249-255
ページ数7
ジャーナルCancer science
96
5
DOI
出版ステータスPublished - 2005 5
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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