Tumor suppression by stromal TIMPs

Masayuki Shimoda, Hartland W. Jackson, Rama Khokha

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and identifies a novel mode of stromal–tumor communication that activates key oncogenic pathways invoving Notch and ras homolog gene family, member A (RhoA) via stromal exosomes.

本文言語English
論文番号e975082
ジャーナルMolecular and Cellular Oncology
3
3
DOI
出版ステータスPublished - 2016 5月 3

ASJC Scopus subject areas

  • 分子医療
  • 癌研究

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