Two cases in which an abnormal hemoglobin (Hb Kamakura) was identified on the basis of an abnormally low glycohemoglobin levels

Yoshifumi Saisho, Fumitake Saitoh, Mitsuhisa Tabata, Toshio Imafuku, Tohru Ogihara, Ikuko Issiki, Yukio Hattori, Yasuhiro Yamashiro

研究成果: Article

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We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.

元の言語English
ページ(範囲)595-598
ページ数4
ジャーナルInternal Medicine
42
発行部数7
DOI
出版物ステータスPublished - 2003 7 1
外部発表Yes

ASJC Scopus subject areas

  • Internal Medicine

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