Two cases of neuroblastoma comprising two distinct clones

Fumito Yamazaki, Atsuko Nakazawa, Tomoo Osumi, Naoki Shimojima, Takeo Tanaka, Akira Nakagawara, Hiroyuki Shimada

研究成果: Article査読

2 被引用数 (Scopus)

抄録

We report two cases of high-risk metastatic neuroblastoma, comprising two biologically distinct components in the adrenal primary tumor, which showed clear differences not only histologically but also in MYCN amplification and HA-RAS/TRKA immunoreactivity (Case 1), anaplastic lymphoma kinase (ALK) immunoreactivity (Case 2). These two cases with multiple separated components were similar to cases classified as ganglioneuroblastoma, nodular subtype (GNBn), in terms of composite tumor. Comparable to the GNBn category, the prognosis of the patients described here may depend on the components with unfavorable histology according to International Neuroblastoma Pathology Classification. Further analyses of such composite neuroblastoma cases are important for assessing disease prognosis.

本文言語English
ページ(範囲)760-762
ページ数3
ジャーナルPediatric Blood and Cancer
61
4
DOI
出版ステータスPublished - 2014 4月

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学

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