TY - JOUR
T1 - Two Cases of Pathological Complete Response to Neoadjuvant Chemoradiation Therapy in Pancreatic Cancer
AU - Fujii-Nishimura, Yoko
AU - Nishiyama, Ryo
AU - Kitago, Minoru
AU - Masugi, Yohei
AU - Ueno, Akihisa
AU - Aiura, Koichi
AU - Kawachi, Shigeyuki
AU - Kawaida, Miho
AU - Abe, Yuta
AU - Shinoda, Masahiro
AU - Itano, Osamu
AU - Tanimoto, Akihiro
AU - Sakamoto, Michiie
AU - Kitagawa, Yuko
PY - 2015
Y1 - 2015
N2 - Neoadjuvant chemoradiation therapy (NACRT) is increasingly used in patients with a potentially or borderline resectable pancreatic ductal adenocarcinoma (PDA) and it has been shown to improve survival and reduce locoregional metastatic disease. It is rare for patients with PDA to have a pathological complete response (pCR) to NACRT, but such patients reportedly have a good prognosis. We report the clinicopathological findings of two cases of pCR to NACRT in PDA. Both patients underwent pancreatectomy after NACRT (5-fluorouracil, mitomycin C, cisplatin, and radiation). Neither had residual invasive carcinoma and both showed extensive fibrotic regions with several ducts regarded as having pancreatic intraepithelial neoplasia 3/carcinoma in situ in their post-therapy specimens. It is noteworthy that both patients had a history of a second primary cancer. They both had comparatively good outcomes: one lived for 9 years after the initial pancreatectomy and the other is still alive without recurrence after 2 years.
AB - Neoadjuvant chemoradiation therapy (NACRT) is increasingly used in patients with a potentially or borderline resectable pancreatic ductal adenocarcinoma (PDA) and it has been shown to improve survival and reduce locoregional metastatic disease. It is rare for patients with PDA to have a pathological complete response (pCR) to NACRT, but such patients reportedly have a good prognosis. We report the clinicopathological findings of two cases of pCR to NACRT in PDA. Both patients underwent pancreatectomy after NACRT (5-fluorouracil, mitomycin C, cisplatin, and radiation). Neither had residual invasive carcinoma and both showed extensive fibrotic regions with several ducts regarded as having pancreatic intraepithelial neoplasia 3/carcinoma in situ in their post-therapy specimens. It is noteworthy that both patients had a history of a second primary cancer. They both had comparatively good outcomes: one lived for 9 years after the initial pancreatectomy and the other is still alive without recurrence after 2 years.
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U2 - 10.2302/kjm.2014-0014-CR
DO - 10.2302/kjm.2014-0014-CR
M3 - Article
C2 - 26118369
SN - 0022-9717
VL - 64
SP - 26
EP - 31
JO - Keio Journal of Medicine
JF - Keio Journal of Medicine
IS - 2
ER -
