抄録
T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.
本文言語 | English |
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ページ(範囲) | 377-383 |
ページ数 | 7 |
ジャーナル | Virus Genes |
巻 | 1 |
号 | 4 |
DOI | |
出版ステータス | Published - 1988 7月 1 |
外部発表 | はい |
ASJC Scopus subject areas
- 分子生物学
- 遺伝学
- ウイルス学