Two major subgroups of human T-Cell leukemia virus-1 in Japan

Haruhiko Siomi, Tetsuya Nosaka, Takahiko Saida, Hiroshi Miwa, Yorio Hinuma, Shigeru Shirakawa, Naoaki Miyamoto, Toshifumi Kondo, Koichi Araki, Michito Ichimaru, Akira B. Miura, Masakazu Hatanaka

研究成果: Article査読

7 被引用数 (Scopus)

抄録

T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.

本文言語English
ページ(範囲)377-383
ページ数7
ジャーナルVirus Genes
1
4
DOI
出版ステータスPublished - 1988 7月 1
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • ウイルス学

フィンガープリント

「Two major subgroups of human T-Cell leukemia virus-1 in Japan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル