Two unprecedented cembrene-type terpenes from an indonesian soft coral sarcophyton sp.

Magie M. Kapojos, Jong Soo Lee, Taiko Oda, Takahiro Nakazawa, Ohgi Takahashi, Kazuyo Ukai, Remy E.P. Mangindaan, Henki Rotinsulu, Defny S. Wewengkang, Sachiko Tsukamoto, Hisayoshi Kobayashi, Michio Namikoshi

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Two unusual cembranoids, sarcofuranocembrenolides A (1) and B (2), were isolated from a soft coral Sarcophyton sp. together with five known cembranoids (3-7). Compound 1 had a unique carbon skeleton of 8,19-bisnorfuranocembrenolide. Compound 2 was a furanocembrenolide, but a C1 unit (C-20) was attached to C-10 instead of C-12 of the ordinary cembrenolides. These rearrangements are unique in the biosynthesis of cembranoid diterpenes. Lobohedleolide (5), (7Z)-lobohedleolide (6), and denticulatolide (7) inhibited the colony formation of V79 cells at ED50 values of 4.6 (abt. 1.52), 3.7 (1.22), and 3.6 (1.40) μM (μg/mL), respectively, and reduced TNF-α production from LPS-stimulated RAW264.7 cells at 3.0-10.0 μM.

本文言語English
ページ(範囲)641-645
ページ数5
ジャーナルTetrahedron
66
3
DOI
出版ステータスPublished - 2010 1 16

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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