Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons

Takafumi Inoue, Kunio Kato, Kazuhisa Kohda, Katsuhiko Mikoshiba

研究成果: Article査読

178 被引用数 (Scopus)

抄録

The inositol 1,4,5-trisphosphate receptor (InsP3R) is an intracellular Ca2+ channel that releases Ca2+ from internal Ca2+ stores in response to InsP3. Although InsP3R is highly expressed in various regions of the mammalian brain, the functional role of this receptor has not been clarified. We show here that cerebellar slices prepared from mice with a disrupted InsP3R type 1 gene, which is predominantly expressed in Purkinje cells, completely lack long-term depression (LTD), a model of synaptic plasticity in the cerebellum. Moreover, a specific antibody against InsP3R1, introduced into wild-type Purkinje cells through patch pipettes, blocked the induction of LTD. These data indicate that, in addition to Ca2+ influx through Ca2+ channels on the plasma membrane, Ca2+ release from InsP3R plays an essential role in the induction of LTD, suggesting a physiological importance for InsP3R in Purkinje cells.

本文言語English
ページ(範囲)5366-5373
ページ数8
ジャーナルJournal of Neuroscience
18
14
DOI
出版ステータスPublished - 1998 7 15

ASJC Scopus subject areas

  • Neuroscience(all)

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