Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

Kenya Honda, Akinori Takaoka, Tadatsugu Taniguchi

研究成果: Review article査読

733 被引用数 (Scopus)

抄録

Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.

本文言語English
ページ(範囲)349-360
ページ数12
ジャーナルImmunity
25
3
DOI
出版ステータスPublished - 2006 9
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

フィンガープリント 「Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル