Ubiquinone-rhodol (UQ-Rh) for fluorescence imaging of NAD(P)H through intracellular activation

Hirokazu Komatsu, Yutaka Shindo, Kotaro Oka, Jonathan P. Hill, Katsuhiko Ariga

研究成果: Article査読

53 被引用数 (Scopus)

抄録

The nicotinamide adenine dinucleotide (NAD) derivatives NADH and NADPH are critical components of cellular energy metabolism and operate as electron carriers. A novel fluorescent ubiquinone-rhodol derivative (UQ-Rh) was developed as a probe for NAD(P)H. By using the artificial promoter [(η5- C5Me5)Ir(phen)(H2O)]2+, intracellular activation and imaging of NAD(P)H were successfully demonstrated. In contrast to bioorthogonal chemistry, this "bioparallel chemistry" approach involves interactions with native biological processes and could potentially be used to control or investigate cellular systems. Active detection: NADH and NADPH are critical components of cellular energy metabolism and operate as electron carriers. A novel fluorescent ubiquinone-rhodol derivative (UQ-Rh) was developed as a probe for NAD(P)H. By using the artificial promoter [(η5-C5Me5)Ir(phen)(H 2O)]2+, intracellular activation and imaging of NAD(P)H were successfully demonstrated.

本文言語English
ページ(範囲)3993-3995
ページ数3
ジャーナルAngewandte Chemie - International Edition
53
15
DOI
出版ステータスPublished - 2014 4 7

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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