Ubiquitin chain diversity at a glance

Masato Akutsu, Ivan Dikic, Anja Bremm

研究成果: Article査読

270 被引用数 (Scopus)

抄録

Ubiquitin plays an essential role in modulating protein functions, and deregulation of the ubiquitin system leads to the development of multiple human diseases. Owing to its molecular features, ubiquitin can form various homo- and heterotypic polymers on substrate proteins, thereby provoking distinct cellular responses. The concept of multifaceted ubiquitin chains encoding different functions has been substantiated in recent years. It has been established that all possible ubiquitin linkage types are utilized for chain assembly and propagation of specific signals in vivo. In addition, branched ubiquitin chains and phosphorylated ubiquitin molecules have been put under the spotlight recently. The development of novel technologies has provided detailed insights into the structure and function of previously poorly understood ubiquitin signals. In this Cell Science at a Glance article and accompanying poster, we provide an update on the complexity of ubiquitin chains and their physiological relevance.

本文言語English
ページ(範囲)875-880
ページ数6
ジャーナルJournal of Cell Science
129
5
DOI
出版ステータスPublished - 2016
外部発表はい

ASJC Scopus subject areas

  • 細胞生物学

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