Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Yasuhiro Igarashi, Daisuke Asano, Masashi Sawamura, Yasuko In, Toshimasa Ishida, Masaya Imoto

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

本文言語English
ページ(範囲)1658-1661
ページ数4
ジャーナルOrganic Letters
18
7
DOI
出版ステータスPublished - 2016 4月 15

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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