Ultrasound-Triggered Drug Release from Hydrogel Microspheres with Release Booster

Takeshi Kubota, Yuta Kurashina, Hiroaki Onoe

研究成果: Conference contribution

抄録

This paper describes ultrasound-triggered drug release from hydrogel microspheres with release booster. As a drug carrier, calcium alginate hydrogel microspheres containing drug model and tungsten particles were fabricated by using a centrifugal microfluidic device. The tungsten particles with high acoustic impedance enable the hydrogel microspheres to have high sensitivity to ultrasound so that the release rate of the drug models improves. By applying ultrasound to the hydrogel microspheres, we confirmed the release of fluorescent silica nanoparticles and protein as a drug model. Importantly, the drug model was released from our hydrogel microspheres even in a cavitation-suppressed environment, indicating that this system could reduce the damage to tissues. Our proposed ultrasound-triggered drug release system using tungsten particles would be an effective on-demand drug delivery system (DDS).

本文言語English
ホスト出版物のタイトル34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021
出版社Institute of Electrical and Electronics Engineers Inc.
ページ26-29
ページ数4
ISBN(電子版)9781665419123
DOI
出版ステータスPublished - 2021 1 25
イベント34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021 - Virtual, Gainesville, United States
継続期間: 2021 1 252021 1 29

出版物シリーズ

名前Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
2021-January
ISSN(印刷版)1084-6999

Conference

Conference34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021
国/地域United States
CityVirtual, Gainesville
Period21/1/2521/1/29

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 機械工学
  • 電子工学および電気工学

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