ULTRASOUND-TRIGGERED ON-DEMAND ADENO-ASSOCIATED-VIRUS RELEASE FROM HYDROGEL MICROBEADS FOR GENE THERAPY

Shuhei Takatsuka, Takeshi Kubota, Yuta Kurashina, Hiroaki Onoe

研究成果: Conference contribution

抄録

This paper reports ultrasound-triggered adeno-associated-virus (AAV) release from alginate hydrogel microbeads loaded into a gelatin hydrogel carrier to promote the transfection of cells. As a AAV carrier, caldium alginate hydrogel microbeads were centrifugally fabricated by ejecting a mixed pre-gel solution composed of sodium alginate, AAV and tungsten particles to CaCl2 solution to form ionically cross-linked instantly. For fixing of the beads, the microbeads were loaded into gelatin hydrogel carriers. The tungsten particles having high acoustic impedance enable the beads to have high sensitivity to ultrasound for improvement of the transfection. Our proposed ultrasound-triggered AAV releasing system would be an effective controlled release system for gene therapy.

本文言語English
ホスト出版物のタイトルMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
出版社Chemical and Biological Microsystems Society
ページ655-656
ページ数2
ISBN(電子版)9781733419031
出版ステータスPublished - 2021
イベント25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
継続期間: 2021 10月 102021 10月 14

出版物シリーズ

名前MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
国/地域United States
CityPalm Springs, Virtual
Period21/10/1021/10/14

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 化学工学(その他)

フィンガープリント

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引用スタイル