We studied whether prophylactic low-intensity ultraviolet light (UV) irradiation reduces development of delayed cerebral vasospasm in rabbit model. Eleven rabbits had carotid angiography and placement of silicon sheaths around the right common carotid artery (CCA). Just before the placement, CCAs of 6 in the 11 animals were adventitiously exposed to UV (10 mJ/mm2) emitted from a helium-cadmium laser (wavelength = 325 nm). Sheaths were filled with autologous blood in all of 11 animals. Vasospasm developed 24 to 48 hours (Day 2) later. The CCA luminal diameter without UV irradiation was 77% of the Day 0 state. The prophylactic laser treatment reduced the development of vasospasm, 90% of the Day 0 state. Histological examination of the treated CCA revealed extended smooth muscle cells. There was no endothelial damage. These results suggest that UV is effective for prophylaxis of cerebral vasospasm.
|ジャーナル||Proceedings of SPIE - The International Society for Optical Engineering|
|出版ステータス||Published - 1999 1月 1|
|イベント||Proceedings of the 1999 Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical - San Jose, CA, USA|
継続期間: 1999 1月 24 → 1999 1月 27
ASJC Scopus subject areas
- コンピュータ サイエンスの応用