Ultraviolet light attenuates vasospasm development: Low intensity 325 nm illumination in animal model

Yuji Morimoto, Kanji Nakai, Tsunenori Arai, Katsuji Shima, Makoto Kikuchi

研究成果: Conference article査読


We studied whether prophylactic low-intensity ultraviolet light (UV) irradiation reduces development of delayed cerebral vasospasm in rabbit model. Eleven rabbits had carotid angiography and placement of silicon sheaths around the right common carotid artery (CCA). Just before the placement, CCAs of 6 in the 11 animals were adventitiously exposed to UV (10 mJ/mm2) emitted from a helium-cadmium laser (wavelength = 325 nm). Sheaths were filled with autologous blood in all of 11 animals. Vasospasm developed 24 to 48 hours (Day 2) later. The CCA luminal diameter without UV irradiation was 77% of the Day 0 state. The prophylactic laser treatment reduced the development of vasospasm, 90% of the Day 0 state. Histological examination of the treated CCA revealed extended smooth muscle cells. There was no endothelial damage. These results suggest that UV is effective for prophylaxis of cerebral vasospasm.

ジャーナルProceedings of SPIE - The International Society for Optical Engineering
出版ステータスPublished - 1999 1 1
イベントProceedings of the 1999 Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical - San Jose, CA, USA
継続期間: 1999 1 241999 1 27

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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