Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

Mika Mizunuma, Hiroaki Norimoto, Kentaro Tao, Takahiro Egawa, Kenjiro Hanaoka, Tetsuya Sakaguchi, Hiroyuki Hioki, Takeshi Kaneko, Shun Yamaguchi, Tetsuo Nagano, Norio Matsuki, Yuji Ikegaya

研究成果: Article査読

50 被引用数 (Scopus)

抄録

Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

本文言語English
ページ(範囲)503-505
ページ数3
ジャーナルNature Neuroscience
17
4
DOI
出版ステータスPublished - 2014 4月
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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