Unexpectedly Efficient Homing Capacity of Purified Murine Hematopoietic Stem Cells

Yumi Matsuzaki, Kentaro Kinjo, Richard C. Mulligan, Hideyuki Okano

研究成果: Article査読

250 被引用数 (Scopus)

抄録

Single-cell transplantation analysis revealed that the cells that had the strongest dye efflux activity ("Tip"-SP cells) and had the phenotype CD34- c-Kit+ Sca-1+ Lin- (CD34- KSL cells) exhibited very strong proliferation and multilineage differentiation capacity. Ninety-six percent of the lethally irradiated mice that received a single "Tip"-SP CD34- KSL cell showed significant donor cell engraftment for long term. These findings support the hypothesis that "Tip"-SP CD34- KSL cells represent the most primitive hematopoietic stem cells that are capable of migrating into the primary site and surviving and/or proliferating with nearly absolute efficiency. This led us to propose high marrow-seeding efficiency as a specific characteristic of primitive HSCs, in addition to their self-renewal and multipotent capacity.

本文言語English
ページ(範囲)87-93
ページ数7
ジャーナルImmunity
20
1
DOI
出版ステータスPublished - 2004 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

フィンガープリント 「Unexpectedly Efficient Homing Capacity of Purified Murine Hematopoietic Stem Cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル