抄録
The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials displayed distinctive features that could not have been predicted from preclinical data. The distribution volumes (0.0796-0.158 liters/kg) and the systemic clearance (0.0407-0.252 ml/h/kg) were extremely low, in contrast to large distribution volume and rapid systemic clearance in experimental animals. The elimination half-lives (253-1660 h) were unusually long. In vitro protein binding experiments demonstrated that UCN-01 was strongly bound to human α1-acid glycoprotein. The results suggest that unusual pharmacokinetics of UCN-01 in humans could be due, at least in part, to its specifically high binding to α1-acid glycoprotein.
本文言語 | English |
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ページ(範囲) | 3248-3253 |
ページ数 | 6 |
ジャーナル | Cancer Research |
巻 | 58 |
号 | 15 |
出版ステータス | Published - 1998 8月 1 |
外部発表 | はい |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究