Up-regulated expression of murine Mcl1/EAT, a Bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells

Hajime Okita, Akihiro Umezawa, Atsushi Suzuki, Jun Ichi Hata

研究成果: Article査読

24 被引用数 (Scopus)

抄録

We have cloned a murine homologue of the human Mcl1/EAT gene, a Bcl-2 related gene. Sequence analysis revealed that murine Mcl1/EAT (mMcl1/EAT) has three Bcl-2 homology domains, two PEST sequences, and immediate response boxes (IRB). The presence of IRB indicates that mMcl1/EAT is an immediate- early gene. mMcl1/EAT increases dramatically with exposure to retinoic acid in murine embryonal carcinoma cell lines (F9 and PCC3) as well as embryonic stem cells, both of which are models of early embryogenesis.

本文言語English
ページ(範囲)335-341
ページ数7
ジャーナルBiochimica et Biophysica Acta - Gene Structure and Expression
1398
3
DOI
出版ステータスPublished - 1998 7 9

ASJC Scopus subject areas

  • 構造生物学
  • 生物理学
  • 生化学
  • 遺伝学

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