Up-regulation of the Ire I-mediated signaling molecule, Bip, in ischemic rat brain

D. Ito, K. Tanaka, S. Suzuki, T. Dembo, A. Kosakai, Y. Fukuuchi

研究成果: Article査読

44 被引用数 (Scopus)

抄録

The endoplasmic reticulum (ER) is thought to play important roles in various neurological diseases via multifactorial and complex mechanisms. The Ire1-mediated signal is part of one ER signaling pathways; the signal induces the expression of an ER-resident protein, Bip/GRP78, and is thought to be involved in cell death under ER stress. In this study, we examined time-dependent Bip expression after transient middle cerebral artery occlusion and characterized the Bip-positive cells. Ire1- mediated molecules, Bip, were rapidly up-regulated in the ischemic area after 3.5 h recirculation. Their immunoreactivity continued to increase until 24-48h. Immunofluorescence staining revealed Bip up-regulation in ischemic neurons, which were TUNEL positive. Our studies suggest that the Ire1-mediated signal might be associated with ischemic neuronal damage.

本文言語English
ページ(範囲)4023-4028
ページ数6
ジャーナルNeuroReport
12
18
DOI
出版ステータスPublished - 2001 12 21

ASJC Scopus subject areas

  • 神経科学(全般)

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