Urinary dysfunction in early and untreated Parkinson's disease

Tomoyuki Uchiyama, Ryuji Sakakibara, Tatsuya Yamamoto, Takashi Ito, Chiharu Yamaguchi, Yusuke Awa, Mitsuru Yanagisawa, Yoshinori Higuchi, Yasunori Sato, Tomohiko Ichikawa, Tomonori Yamanishi, Takamichi Hattori, Satoshi Kuwabara

研究成果: Article査読

67 被引用数 (Scopus)

抄録

Background: Urinary dysfunction is common in Parkinson's disease (PD); however, little is known about urinary dysfunction in early and untreated PD patients. Methods: Fifty consecutive untreated PD patients (mean age, 66.7; mean disease duration, 23.6 months; and mean Hoehn & Yahr scale, 1.9) were recruited; those with other conditions that might have influenced urinary function were excluded. Patients were evaluated using a urinary questionnaire and urodynamic studies. Results: Sixty-four per cent complained of urinary symptoms (storage, 64.0%; voiding, 28.0%). Urodynamic studies showed abnormal findings in the storage phase in 84%, with detrusor overactivity (DO) and increased bladder sensation without DO in 58.0% and 12.0% of patients, respectively. In the voiding phase, detrusor underactivity, impaired urethral relaxation such as detrusor sphincter dyssynergia, and bladder outlet obstruction were present in 50.0%, 8.0% and 16% of patients, respectively. In patients with both storage and voiding phase abnormalities, DO+detrusor underactivity was the most common finding. Few patients experienced urge incontinence and/or quality-of-life impairment owing to urinary dysfunction; none had low-compliance bladder or abnormal anal-sphincter motor unit potential. These urinary symptoms and urodynamic findings were not correlated with gender, disease severity or motor symptom type. Conclusion: Urinary dysfunction, manifested primarily as storage disorders with subclinical voiding disorders and normal anal-sphincter electromyography, occurs in early and untreated PD patients. In cases with severe voiding disorder and/or abnormal anal-sphincter electromyography, other diagnoses should be considered.

本文言語English
ページ(範囲)1382-1386
ページ数5
ジャーナルJournal of Neurology, Neurosurgery and Psychiatry
82
12
DOI
出版ステータスPublished - 2011 12
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 臨床神経学
  • 精神医学および精神衛生

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