Urinary podocalyxin levels were associated with urinary albumin levels among patients with diabetes

M. Shoji, K. Kobayashi, M. Takemoto, Y. Sato, K. Yokote

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Diabetic nephropathy has dramatically increased worldwide. In this study, we measured urinary podocalyxin in 240 patients with diabetes. The relationship between urinary podocalyxin and clinical parameters and the effects of dipeptidyl peptidase-4 inhibitors (DPP4i) and alpha-glucosidase inhibitor (a-GI) on urinary podocalyxin levels were examined. Urinary podocalyxin levels were significantly higher in patients with microalbuminuria than in those with normoalbuminuria. Urinary podocalyxin levels were also significantly related to albumin-to-creatinine ratio. Neither DPP4i nor α-GI ameliorated the increase in urinary podocalyxin levels. Our results indicated that urinary podocalyxin will be not only an early marker but also a treatment target for DN.

本文言語English
ページ(範囲)164-167
ページ数4
ジャーナルBiomarkers
21
2
DOI
出版ステータスPublished - 2016 2月 17
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 臨床生化学
  • 健康、毒物学および変異誘発

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