抄録
In this review, we will focus on urinary steroid profiling by gas chromatography mass spectrometry (GC/MS) and summarize its contribution to the diagnosis of abnormal steroidogenesis; congenital enzyme deficiency of steroid synthesis and metabolism, adrenal carcinoma and other steroid related diseases. Mass spectrometry technique, such as GC/MS and liquid chromatography tandem mass spectrometry (LC-MS/MS), has become the main tool for steroid measurement and GC/MS is mainly used for urine sampling. We will discuss the pros and cons of urinary steroid profiling by GC/MS and LC-MS/MS. Although GC/MS analysis needs intricate pretreatment, time and expenses, sensitive and simultaneous measurement of whole pathway steroid measurements have improved the accuracy of diagnosis.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 273-282 |
| ページ数 | 10 |
| ジャーナル | Expert Review of Endocrinology and Metabolism |
| 巻 | 9 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | Published - 2014 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
これを引用
Urinary steroid profiling : A powerful method for the diagnosis of abnormal steroidogenesis. / Koyama, Yuhei; Homma, Keiko; Hasegawa, Tomonobu.
：: Expert Review of Endocrinology and Metabolism, 巻 9, 番号 3, 2014, p. 273-282.研究成果: Article
}
TY - JOUR
T1 - Urinary steroid profiling
T2 - A powerful method for the diagnosis of abnormal steroidogenesis
AU - Koyama, Yuhei
AU - Homma, Keiko
AU - Hasegawa, Tomonobu
PY - 2014
Y1 - 2014
N2 - In this review, we will focus on urinary steroid profiling by gas chromatography mass spectrometry (GC/MS) and summarize its contribution to the diagnosis of abnormal steroidogenesis; congenital enzyme deficiency of steroid synthesis and metabolism, adrenal carcinoma and other steroid related diseases. Mass spectrometry technique, such as GC/MS and liquid chromatography tandem mass spectrometry (LC-MS/MS), has become the main tool for steroid measurement and GC/MS is mainly used for urine sampling. We will discuss the pros and cons of urinary steroid profiling by GC/MS and LC-MS/MS. Although GC/MS analysis needs intricate pretreatment, time and expenses, sensitive and simultaneous measurement of whole pathway steroid measurements have improved the accuracy of diagnosis.
AB - In this review, we will focus on urinary steroid profiling by gas chromatography mass spectrometry (GC/MS) and summarize its contribution to the diagnosis of abnormal steroidogenesis; congenital enzyme deficiency of steroid synthesis and metabolism, adrenal carcinoma and other steroid related diseases. Mass spectrometry technique, such as GC/MS and liquid chromatography tandem mass spectrometry (LC-MS/MS), has become the main tool for steroid measurement and GC/MS is mainly used for urine sampling. We will discuss the pros and cons of urinary steroid profiling by GC/MS and LC-MS/MS. Although GC/MS analysis needs intricate pretreatment, time and expenses, sensitive and simultaneous measurement of whole pathway steroid measurements have improved the accuracy of diagnosis.
KW - Adrenal tumor
KW - Congenital adrenal hyperplasia
KW - Gas chromatography mass spectrometry
KW - Steroid profiling
KW - Urinary steroid metabolites
UR - http://www.scopus.com/inward/record.url?scp=84899102927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899102927&partnerID=8YFLogxK
U2 - 10.1586/17446651.2014.904199
DO - 10.1586/17446651.2014.904199
M3 - Article
AN - SCOPUS:84899102927
VL - 9
SP - 273
EP - 282
JO - Expert Review of Endocrinology and Metabolism
JF - Expert Review of Endocrinology and Metabolism
SN - 1744-6651
IS - 3
ER -