Urinary steroid profiling: A powerful method for the diagnosis of abnormal steroidogenesis

Yuhei Koyama, Keiko Homma, Tomonobu Hasegawa

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

In this review, we will focus on urinary steroid profiling by gas chromatography mass spectrometry (GC/MS) and summarize its contribution to the diagnosis of abnormal steroidogenesis; congenital enzyme deficiency of steroid synthesis and metabolism, adrenal carcinoma and other steroid related diseases. Mass spectrometry technique, such as GC/MS and liquid chromatography tandem mass spectrometry (LC-MS/MS), has become the main tool for steroid measurement and GC/MS is mainly used for urine sampling. We will discuss the pros and cons of urinary steroid profiling by GC/MS and LC-MS/MS. Although GC/MS analysis needs intricate pretreatment, time and expenses, sensitive and simultaneous measurement of whole pathway steroid measurements have improved the accuracy of diagnosis.

本文言語English
ページ(範囲)273-282
ページ数10
ジャーナルExpert Review of Endocrinology and Metabolism
9
3
DOI
出版ステータスPublished - 2014 5

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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