Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Yuki Kanamori, Arihiro Iwasaki, Shinpei Sumimoto, Kiyotake Suenaga

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

本文言語English
ページ(範囲)4213-4216
ページ数4
ジャーナルTetrahedron Letters
57
37
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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