Use of a new ICG-dye-enhanced diode laser for percutaneous laser disc decompression

Masato Sato, Miya Ishihara, Tsunenori Arai, Takashi Asazuma, Toshiyuki Kikuchi, Takuya Hayashi, Takahiro Yamada, Makoto Kikuchi, Kyosuke Fujikawa

研究成果: Article

22 引用 (Scopus)

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Background and Objective: The lasers used today for Percutaneous Laser Disc Decompression (PLDD) can not selectively ablate the nucleus pulposus (NP). We hypothesized that if indocyanine green dye were injected into the NP, 805 nm diode laser irradiation would result in selective and safe removal of NP tissue without damaging nearby tissues. Study Design/Materials and Methods: Twelve beagle dogs were used for three experiments, i.e., determination of attenuation coefficients of NP and AF, determination of weight of NP before and after laser irradiation, and histopathological study. Results: The attenuation coefficient at 805 nm of NP which had been homogenized in the presence of ICG was 2521.3/cm. Upon application of the diode laser at a power of 1, 3, or 5 W (the intensity of laser irradiation: 0.353, 1.061, or 1.768 x 103 W/cM2) to NPs into which ICG had been injected, the weight of the NPs decreased by a mean 20, 45, and 65%, respectively. Macroscopic and microscopic examination of the discs after PLDD showed that only the NP where the tissues were stained by ICG were removed. Conclusions: These results indicated that the combined use of ICG and diode laser irradiation effectively and selectively ablates the NP with low laser power.

元の言語English
ページ(範囲)282-287
ページ数6
ジャーナルLasers in Surgery and Medicine
29
発行部数3
DOI
出版物ステータスPublished - 2001 10 20

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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    Sato, M., Ishihara, M., Arai, T., Asazuma, T., Kikuchi, T., Hayashi, T., Yamada, T., Kikuchi, M., & Fujikawa, K. (2001). Use of a new ICG-dye-enhanced diode laser for percutaneous laser disc decompression. Lasers in Surgery and Medicine, 29(3), 282-287. https://doi.org/10.1002/lsm.1120