Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly-DL-lactic-co-glycolic acid (PLGA)-collagen sponge

Kensuke Ochi, Gouping Chen, Takashi Ushida, Satoshi Gojo, Kaoru Segawa, Hitoshi Tai, Kenju Ueno, Hiroyuki Ohkawa, Taisuke Mori, Akira Yamaguchi, Yoshiaki Toyama, Jun Ichi Hata, Akihiro Umezawa

研究成果: Article査読

73 被引用数 (Scopus)

抄録

Control led regeneration of bone or cartilage has recently begun to facilitate a host of novel clinical treatments. An osteoblast line, which we isolated is able to form new bone matrix in vivo within 2 days and exhibits a mature osteoblast phenotype both in vitro and in vivo. Using these cells, we show that cuboidal bones can be generated into a predesigned shaped-bone with high-density bone trabeculae when used in combination with a modified poly -DL-lactic-co-glycolic acid (PLGA)-collagen sponge. PLGA coated with collagen gel serves as a good scaffold for osteoblasts. These results indicate that mature osteoblasts, in combination with a scaffold such as PLGA-collagen sponge, show promise for use in a custom-shaped bone regeneration tool for both basic research into osteogenesis and for development of therapeutic applications.

本文言語English
ページ(範囲)45-53
ページ数9
ジャーナルJournal of Cellular Physiology
194
1
DOI
出版ステータスPublished - 2003 1 1

ASJC Scopus subject areas

  • 生理学
  • 臨床生化学
  • 細胞生物学

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