Use of perfluorocarboxylic acids to trick cytochrome P450BM3 into initiating the hydroxylation of gaseous alkanes

Norifumi Kawakami; Osami Shoji; Yoshihito Watanabe

doi:10.1002/anie.201007975

Use of perfluorocarboxylic acids to trick cytochrome P450BM3 into initiating the hydroxylation of gaseous alkanes

Norifumi Kawakami, Osami Shoji, Yoshihito Watanabe

研究成果: Article › 査読

105 被引用数 (Scopus)

抄録

It has long been believed that the fatty acid hydroxylase wild-type P450BM3 is unable to oxidize gaseous alkanes. However, the simple addition of a perfluorocarboxylic acid as a dummy substrate to initiate the P450BM3 catalytic cycle enabled the efficient hydroxylation of butane and propane (see picture).

本文言語	English
ページ（範囲）	5315-5318
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	50
号	23
DOI	https://doi.org/10.1002/anie.201007975
出版ステータス	Published - 2011 5月 27
外部発表	はい

ASJC Scopus subject areas

触媒
化学 (全般)

文献へのアクセス

10.1002/anie.201007975

他のファイルとリンク

引用スタイル

@article{491b99e36c664971af8eb5205f3f3e0f,

title = "Use of perfluorocarboxylic acids to trick cytochrome P450BM3 into initiating the hydroxylation of gaseous alkanes",

abstract = "It has long been believed that the fatty acid hydroxylase wild-type P450BM3 is unable to oxidize gaseous alkanes. However, the simple addition of a perfluorocarboxylic acid as a dummy substrate to initiate the P450BM3 catalytic cycle enabled the efficient hydroxylation of butane and propane (see picture).",

keywords = "cytochromes, enzyme catalysis, gaseous alkanes, hydroxylation, perfluorocarboxylic acids",

author = "Norifumi Kawakami and Osami Shoji and Yoshihito Watanabe",

year = "2011",

month = may,

day = "27",

doi = "10.1002/anie.201007975",

language = "English",

volume = "50",

pages = "5315--5318",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "23",

}

TY - JOUR

T1 - Use of perfluorocarboxylic acids to trick cytochrome P450BM3 into initiating the hydroxylation of gaseous alkanes

AU - Kawakami, Norifumi

AU - Shoji, Osami

AU - Watanabe, Yoshihito

PY - 2011/5/27

Y1 - 2011/5/27

N2 - It has long been believed that the fatty acid hydroxylase wild-type P450BM3 is unable to oxidize gaseous alkanes. However, the simple addition of a perfluorocarboxylic acid as a dummy substrate to initiate the P450BM3 catalytic cycle enabled the efficient hydroxylation of butane and propane (see picture).

AB - It has long been believed that the fatty acid hydroxylase wild-type P450BM3 is unable to oxidize gaseous alkanes. However, the simple addition of a perfluorocarboxylic acid as a dummy substrate to initiate the P450BM3 catalytic cycle enabled the efficient hydroxylation of butane and propane (see picture).

KW - cytochromes

KW - enzyme catalysis

KW - gaseous alkanes

KW - hydroxylation

KW - perfluorocarboxylic acids

UR - http://www.scopus.com/inward/record.url?scp=79957489869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957489869&partnerID=8YFLogxK

U2 - 10.1002/anie.201007975

DO - 10.1002/anie.201007975

M3 - Article

C2 - 21506212

AN - SCOPUS:79957489869

SN - 1433-7851

VL - 50

SP - 5315

EP - 5318

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 23

ER -

Use of perfluorocarboxylic acids to trick cytochrome P450BM3 into initiating the hydroxylation of gaseous alkanes

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル