抄録
Background: The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma. Case Report: The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor. The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV. Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results. Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely. Conclusion: The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 137-141 |
| ページ数 | 5 |
| ジャーナル | Chemotherapy |
| 巻 | 53 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 2007 3 |
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ASJC Scopus subject areas
- Pharmacology (medical)
これを引用
Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma : A case report. / Yamagami, Wataru; Banno, Kouji; Kawaguchi, Makiko; Yanokura, Megumi; Kuwabara, Yoshiko; Hirao, Nobumaru; Susumu, Nobuyuki; Tsukazaki, Katsumi; Aoki, Daisuke.
：: Chemotherapy, 巻 53, 番号 2, 03.2007, p. 137-141.研究成果: Article
}
TY - JOUR
T1 - Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma
T2 - A case report
AU - Yamagami, Wataru
AU - Banno, Kouji
AU - Kawaguchi, Makiko
AU - Yanokura, Megumi
AU - Kuwabara, Yoshiko
AU - Hirao, Nobumaru
AU - Susumu, Nobuyuki
AU - Tsukazaki, Katsumi
AU - Aoki, Daisuke
PY - 2007/3
Y1 - 2007/3
N2 - Background: The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma. Case Report: The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor. The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV. Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results. Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely. Conclusion: The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.
AB - Background: The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma. Case Report: The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor. The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV. Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results. Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely. Conclusion: The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.
KW - Adenocarcinoma
KW - Adjuvant chemotherapy
KW - Collagen gel droplet embedded culture drug sensitivity test
KW - Mature cystic teratoma
UR - http://www.scopus.com/inward/record.url?scp=33847766570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847766570&partnerID=8YFLogxK
U2 - 10.1159/000099985
DO - 10.1159/000099985
M3 - Article
C2 - 17308380
AN - SCOPUS:33847766570
VL - 53
SP - 137
EP - 141
JO - Chemotherapy
JF - Chemotherapy
SN - 0009-3165
IS - 2
ER -