Usefulness and limitation of measurement of insulin-like growth factor binding protein-3 (IGFBP-3) for diagnosis of growth hormone deficiency

Y. Hasegawa, Tomonobu Hasegawa, T. Aso, S. Kotoh, Y. Tsuchiya, O. Nose, Y. Ohyama, K. Araki, T. Tanaka, S. Saisyo, S. Yokoya, Y. Nishi, S. Miyamoto, N. Sasaki, M. Stene

研究成果: Article

33 引用 (Scopus)

抄録

To analyze the utility of insulin-like growth factor binding protein-3 (IGFBP-3) radioimmunoassay for diagnosis of growth hormone deficiency (GHD) we measured IGFBP-3 in sera from normal children, short children and patients with GHD. The sensitivity (true positive ratio) of IGFBP-3 for complete GHD (cGHD) was 93%, while the specificity (true negative ratio) for normal short children (NS) was 88%. In contrast, the sensitivity of IGFBP-3 for partial GHD (pGHD) was only 43%. The poor discrimination between patients with pGHD and NS may be the result of their relatively similar GH level, as compared to cGHD, or due to the limitations of GH stimulation tests. The specificity of IGFBP-3 for NS was excellent in children of all ages: less than 10 years old (87%) and older than 10 (88%). However, sensitivity for GHD was good for children less than 10 years old (84%) but poor for children older than 10 (64%). IGFBP-3 may be less sensitive for diagnosing GHD in older children because IGFBP-3 levels may also increase during puberty due to mechanisms independent of the GH-IGF-I axis.

元の言語English
ページ(範囲)585-591
ページ数7
ジャーナルEndocrinologia Japonica
39
発行部数6
出版物ステータスPublished - 1992
外部発表Yes

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Insulin-Like Growth Factor Binding Protein 3
Growth Hormone
Puberty
Insulin-Like Growth Factor I
Radioimmunoassay

ASJC Scopus subject areas

  • Endocrinology

これを引用

Usefulness and limitation of measurement of insulin-like growth factor binding protein-3 (IGFBP-3) for diagnosis of growth hormone deficiency. / Hasegawa, Y.; Hasegawa, Tomonobu; Aso, T.; Kotoh, S.; Tsuchiya, Y.; Nose, O.; Ohyama, Y.; Araki, K.; Tanaka, T.; Saisyo, S.; Yokoya, S.; Nishi, Y.; Miyamoto, S.; Sasaki, N.; Stene, M.

:: Endocrinologia Japonica, 巻 39, 番号 6, 1992, p. 585-591.

研究成果: Article

Hasegawa, Y, Hasegawa, T, Aso, T, Kotoh, S, Tsuchiya, Y, Nose, O, Ohyama, Y, Araki, K, Tanaka, T, Saisyo, S, Yokoya, S, Nishi, Y, Miyamoto, S, Sasaki, N & Stene, M 1992, 'Usefulness and limitation of measurement of insulin-like growth factor binding protein-3 (IGFBP-3) for diagnosis of growth hormone deficiency', Endocrinologia Japonica, 巻. 39, 番号 6, pp. 585-591.
Hasegawa, Y. ; Hasegawa, Tomonobu ; Aso, T. ; Kotoh, S. ; Tsuchiya, Y. ; Nose, O. ; Ohyama, Y. ; Araki, K. ; Tanaka, T. ; Saisyo, S. ; Yokoya, S. ; Nishi, Y. ; Miyamoto, S. ; Sasaki, N. ; Stene, M. / Usefulness and limitation of measurement of insulin-like growth factor binding protein-3 (IGFBP-3) for diagnosis of growth hormone deficiency. :: Endocrinologia Japonica. 1992 ; 巻 39, 番号 6. pp. 585-591.
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abstract = "To analyze the utility of insulin-like growth factor binding protein-3 (IGFBP-3) radioimmunoassay for diagnosis of growth hormone deficiency (GHD) we measured IGFBP-3 in sera from normal children, short children and patients with GHD. The sensitivity (true positive ratio) of IGFBP-3 for complete GHD (cGHD) was 93{\%}, while the specificity (true negative ratio) for normal short children (NS) was 88{\%}. In contrast, the sensitivity of IGFBP-3 for partial GHD (pGHD) was only 43{\%}. The poor discrimination between patients with pGHD and NS may be the result of their relatively similar GH level, as compared to cGHD, or due to the limitations of GH stimulation tests. The specificity of IGFBP-3 for NS was excellent in children of all ages: less than 10 years old (87{\%}) and older than 10 (88{\%}). However, sensitivity for GHD was good for children less than 10 years old (84{\%}) but poor for children older than 10 (64{\%}). IGFBP-3 may be less sensitive for diagnosing GHD in older children because IGFBP-3 levels may also increase during puberty due to mechanisms independent of the GH-IGF-I axis.",
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AU - Hasegawa, Tomonobu

AU - Aso, T.

AU - Kotoh, S.

AU - Tsuchiya, Y.

AU - Nose, O.

AU - Ohyama, Y.

AU - Araki, K.

AU - Tanaka, T.

AU - Saisyo, S.

AU - Yokoya, S.

AU - Nishi, Y.

AU - Miyamoto, S.

AU - Sasaki, N.

AU - Stene, M.

PY - 1992

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N2 - To analyze the utility of insulin-like growth factor binding protein-3 (IGFBP-3) radioimmunoassay for diagnosis of growth hormone deficiency (GHD) we measured IGFBP-3 in sera from normal children, short children and patients with GHD. The sensitivity (true positive ratio) of IGFBP-3 for complete GHD (cGHD) was 93%, while the specificity (true negative ratio) for normal short children (NS) was 88%. In contrast, the sensitivity of IGFBP-3 for partial GHD (pGHD) was only 43%. The poor discrimination between patients with pGHD and NS may be the result of their relatively similar GH level, as compared to cGHD, or due to the limitations of GH stimulation tests. The specificity of IGFBP-3 for NS was excellent in children of all ages: less than 10 years old (87%) and older than 10 (88%). However, sensitivity for GHD was good for children less than 10 years old (84%) but poor for children older than 10 (64%). IGFBP-3 may be less sensitive for diagnosing GHD in older children because IGFBP-3 levels may also increase during puberty due to mechanisms independent of the GH-IGF-I axis.

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