Utility of birefringence changes due to collagen thermal denaturation rate process analysis: Vessel wall temperature estimation for new short term heating balloon angioplasty

Kenji Kaneko, Natsumi Shimazaki, Maya Gotoh, Eriko Nakatani, Tsunenori Arai

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

Our photo thermal reaction heating architecture balloon realizes less than 10 s short term heating that can soften vessel wall collagen without damaging surrounding tissue thermally. New thermal balloon angioplasty, photo-thermo dynamic balloon angioplasty (PTDBA) has experimentally shown sufficient opening with 2 atm low pressure dilation and prevention of chronic phase restenosis and acute phase thrombus in vivo. Even though PTDBA has high therapeutic potential, the most efficient heating condition is still under study, because relationship of treatment and thermal dose to vessel wall is not clarified yet. To study and set the most efficient heating condition, we have been working on establishment of temperature history estimation method from our previous experimental results. Heating target of PTDBA, collagen, thermally denatures following rate process. Denaturation is able to be quantified with measured collagen birefringence value. To express the denaturation with equation of rate process, the following ex vivo experiments were performed. Porcine extracted carotid artery was soaked in two different temperature saline baths to enforce constant temperature heating. Higher temperature bath was set to 40 to 80 °C and soaking duration was 5 to 40 s. Samples were observed by a polarizing microscope and a scanning electron microscope. The birefringence was measured by polarizing microscopic system using Brace-Koehler compensator 1/30 A. The measured birefringence showed temperature dependency and quite fit with the rate process equation. We think vessel wall temperature is able to be estimated using the birefringence changes due to thermal denaturation.

本文言語English
ホスト出版物のタイトルOptical Interactions with Tissue and Cells XVIII
DOI
出版ステータスPublished - 2007
外部発表はい
イベントOptical Interactions with Tissue and Cells XVIII - San Jose, CA, United States
継続期間: 2007 1 222007 1 24

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
6435
ISSN(印刷版)1605-7422

Other

OtherOptical Interactions with Tissue and Cells XVIII
国/地域United States
CitySan Jose, CA
Period07/1/2207/1/24

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

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